#------------------------------------------------------------------------------ #$Date: 2013-08-29 18:37:19 +0300 (Thu, 29 Aug 2013) $ #$Revision: 88064 $ #$URL: file:///home/coder/svn-repositories/cod/cif/2/01/80/2018056.cif $ #------------------------------------------------------------------------------ # # This file is available in the Crystallography Open Database (COD), # http://www.crystallography.net/. The original data for this entry # were provided by IUCr Journals, http://journals.iucr.org/. # # The file may be used within the scientific community so long as # proper attribution is given to the journal article from which the # data were obtained. # data_2018056 loop_ _publ_author_name 'Frampton, Christopher S.' 'MacNicol, David D.' 'Wilson, Derek R.' _publ_section_title ; (R)-4-(4-Aminophenyl)-2,2,4-trimethylchroman and (S)-4-(4-aminophenyl)-2,2,4-trimethylthiachroman ; _journal_coeditor_code BM3104 _journal_issue 5 _journal_name_full 'Acta Crystallographica Section C' _journal_page_first o188 _journal_page_last o191 _journal_volume 67 _journal_year 2011 _chemical_formula_iupac 'C18 H21 N S' _chemical_formula_moiety 'C18 H21 N S' _chemical_formula_sum 'C18 H21 N S' _chemical_formula_weight 283.42 _chemical_name_common ; Thiadianin's amine ; _chemical_name_systematic ; (S)-4-(4-Aminophenyl)-2,2,4-trimethylthiachroman ; _space_group_IT_number 19 _space_group_name_Hall 'P 2ac 2ab' _space_group_name_H-M_alt 'P 21 21 21' _symmetry_cell_setting orthorhombic _symmetry_space_group_name_Hall 'P 2ac 2ab' _symmetry_space_group_name_H-M 'P 21 21 21' _atom_sites_solution_hydrogens geom _atom_sites_solution_primary direct _atom_sites_solution_secondary difmap _audit_creation_method SHELXL97 _cell_angle_alpha 90.00 _cell_angle_beta 90.00 _cell_angle_gamma 90.00 _cell_formula_units_Z 4 _cell_length_a 10.6043(6) _cell_length_b 10.4104(5) _cell_length_c 13.4126(6) _cell_measurement_reflns_used 5377 _cell_measurement_temperature 100.0(10) _cell_measurement_theta_max 75.7604 _cell_measurement_theta_min 3.2923 _cell_volume 1480.68(13) _computing_cell_refinement 'CrysAlisPro (Agilent Technologies, 2010)' _computing_data_collection 'CrysAlisPro (Agilent Technologies, 2010)' _computing_data_reduction 'CrysAlisPro (Agilent Technologies, 2010)' _computing_molecular_graphics ; SHELXTL (Sheldrick, 2008) and Mercury (Version 2.4; Macrae et al., 2008) ; _computing_publication_material ; SHELXTL (Sheldrick, 2008) and Mercury (Version 2.4; Macrae et al., 2008) ; _computing_structure_refinement 'SHELXTL (Sheldrick, 2008)' _computing_structure_solution 'SHELXTL (Sheldrick, 2008)' _diffrn_ambient_temperature 100.0(10) _diffrn_detector_area_resol_mean 10.5598 _diffrn_measured_fraction_theta_full 0.994 _diffrn_measured_fraction_theta_max 0.994 _diffrn_measurement_device_type 'Agilent SuperNova Dual (Cu at zero) with Atlas detector' _diffrn_measurement_method \w _diffrn_radiation_monochromator mirror _diffrn_radiation_source 'SuperNova (Cu) X-ray Source' _diffrn_radiation_type 'Cu K\a' _diffrn_radiation_wavelength 1.54178 _diffrn_reflns_av_R_equivalents 0.0188 _diffrn_reflns_av_sigmaI/netI 0.0220 _diffrn_reflns_limit_h_max 13 _diffrn_reflns_limit_h_min -13 _diffrn_reflns_limit_k_max 13 _diffrn_reflns_limit_k_min -11 _diffrn_reflns_limit_l_max 16 _diffrn_reflns_limit_l_min -11 _diffrn_reflns_number 6825 _diffrn_reflns_theta_full 74.48 _diffrn_reflns_theta_max 74.48 _diffrn_reflns_theta_min 8.91 _diffrn_standards_number 0 _exptl_absorpt_coefficient_mu 1.830 _exptl_absorpt_correction_T_max 1.00000 _exptl_absorpt_correction_T_min 0.65435 _exptl_absorpt_correction_type multi-scan _exptl_absorpt_process_details '(CrysAlisPro; Agilent Technologies, 2010)' _exptl_crystal_colour colourless _exptl_crystal_density_diffrn 1.271 _exptl_crystal_density_method 'not measured' _exptl_crystal_description block _exptl_crystal_F_000 608 _exptl_crystal_size_max 0.50 _exptl_crystal_size_mid 0.45 _exptl_crystal_size_min 0.20 _refine_diff_density_max 0.226 _refine_diff_density_min -0.262 _refine_ls_abs_structure_details 'Flack (1983), with 1281 Friedel pairs' _refine_ls_abs_structure_Flack 0.016(11) _refine_ls_extinction_method none _refine_ls_goodness_of_fit_ref 1.004 _refine_ls_hydrogen_treatment mixed _refine_ls_matrix_type full _refine_ls_number_parameters 193 _refine_ls_number_reflns 3015 _refine_ls_number_restraints 0 _refine_ls_restrained_S_all 1.004 _refine_ls_R_factor_all 0.0276 _refine_ls_R_factor_gt 0.0272 _refine_ls_shift/su_max 0.001 _refine_ls_shift/su_mean 0.000 _refine_ls_structure_factor_coef Fsqd _refine_ls_weighting_details 'calc w = 1/[\s^2^(Fo^2^)+(0.0510P)^2^+0.1850P] where P=(Fo^2^+2Fc^2^)/3' _refine_ls_weighting_scheme calc _refine_ls_wR_factor_gt 0.0693 _refine_ls_wR_factor_ref 0.0697 _reflns_number_gt 2976 _reflns_number_total 3015 _reflns_threshold_expression I>2\s(I) _[local]_cod_data_source_file bm3104.cif _[local]_cod_data_source_block IV _cod_database_code 2018056 _iucr_refine_instruction_details ; TITL p11025_11 in P2(1)2(1)2(1) CELL 1.54178 10.6043 10.4104 13.4126 90.000 90.000 90.000 ZERR 4.00 0.0006 0.0005 0.0006 0.000 0.000 0.000 LATT -1 SYMM 0.5-X, -Y, 0.5+Z SYMM -X, 0.5+Y, 0.5-Z SYMM 0.5+X, 0.5-Y, -Z SFAC C H N S UNIT 72 84 4 4 SIZE 0.50 0.45 0.20 TEMP -173 SHEL 5.00 0.80 L.S. 12 BOND $H CONF ACTA EQIV $1 -1.00+X, 0.00+Y, 0.00+Z HTAB N1 S1_$1 RTAB DIST C17 C18 WPDB -1 MPLA 5 S1 C10 C5 C4 C3 C2 MPLA 6 C5 C6 C7 C8 C9 C10 S1 C4 MPLA 6 C11 C12 C13 C14 C15 C16 C4 N1 FMAP 2 PLAN -9 TWIN WGHT 0.051000 0.185000 BASF 0.01563 FVAR 0.28888 S1 4 0.388965 0.915465 0.368862 11.00000 0.01732 0.01801 = 0.02245 -0.00267 -0.00470 0.00423 N1 3 -0.313098 0.855850 0.498014 11.00000 0.01782 0.02422 = 0.03228 0.00098 0.00482 -0.00561 H1A 2 -0.383817 0.846090 0.464419 11.00000 0.02518 H1B 2 -0.294396 0.788310 0.542940 11.00000 0.03513 C2 1 0.332545 0.878193 0.243444 11.00000 0.01493 0.01743 = 0.01820 -0.00145 0.00250 0.00165 C3 1 0.188199 0.885968 0.246549 11.00000 0.01381 0.01524 = 0.01686 -0.00160 0.00012 0.00036 AFIX 23 H3A 2 0.158197 0.820457 0.294508 11.00000 -1.20000 H3B 2 0.156344 0.860672 0.180003 11.00000 -1.20000 AFIX 0 C4 1 0.124540 1.016315 0.274772 11.00000 0.01418 0.01274 = 0.01542 0.00065 -0.00164 -0.00022 C5 1 0.204059 1.102347 0.343880 11.00000 0.01425 0.01373 = 0.01529 0.00132 0.00151 -0.00157 C6 1 0.157409 1.224342 0.367868 11.00000 0.01840 0.01517 = 0.02312 0.00022 -0.00139 0.00051 AFIX 43 H6A 2 0.079405 1.250820 0.339743 11.00000 -1.20000 AFIX 0 C7 1 0.220476 1.308170 0.431061 11.00000 0.02247 0.01538 = 0.02461 -0.00255 0.00222 -0.00157 AFIX 43 H7A 2 0.186073 1.390434 0.445206 11.00000 -1.20000 AFIX 0 C8 1 0.334990 1.270651 0.473736 11.00000 0.02116 0.01900 = 0.01865 -0.00149 0.00128 -0.00680 AFIX 43 H8A 2 0.379000 1.326654 0.517515 11.00000 -1.20000 AFIX 0 C9 1 0.382922 1.151185 0.451260 11.00000 0.01525 0.02240 = 0.01679 0.00169 -0.00094 -0.00366 AFIX 43 H9A 2 0.460947 1.125304 0.479682 11.00000 -1.20000 AFIX 0 C10 1 0.319128 1.067231 0.387490 11.00000 0.01477 0.01441 = 0.01586 0.00140 0.00229 -0.00114 C11 1 0.003438 0.981059 0.331434 11.00000 0.01476 0.00919 = 0.01802 -0.00167 0.00008 0.00023 C12 1 -0.117729 0.990606 0.292907 11.00000 0.01682 0.01445 = 0.02015 0.00039 -0.00340 0.00102 AFIX 43 H12A 2 -0.129651 1.027239 0.228724 11.00000 -1.20000 AFIX 0 C13 1 -0.222318 0.947585 0.346387 11.00000 0.01368 0.01758 = 0.02629 -0.00071 -0.00301 0.00135 AFIX 43 H13A 2 -0.303972 0.954683 0.317773 11.00000 -1.20000 AFIX 0 C14 1 -0.208984 0.894500 0.440865 11.00000 0.01612 0.01175 = 0.02471 -0.00308 0.00349 -0.00218 C15 1 -0.087451 0.887031 0.481415 11.00000 0.01875 0.01432 = 0.01897 -0.00025 0.00006 0.00012 AFIX 43 H15A 2 -0.075813 0.853035 0.546498 11.00000 -1.20000 AFIX 0 C16 1 0.015286 0.928679 0.427495 11.00000 0.01493 0.01278 = 0.01756 -0.00188 -0.00194 0.00004 AFIX 43 H16A 2 0.096878 0.921742 0.456242 11.00000 -1.20000 AFIX 0 C17 1 0.095058 1.090650 0.177998 11.00000 0.02028 0.01903 = 0.01800 0.00371 -0.00173 -0.00001 AFIX 137 H17A 2 0.049836 1.169990 0.194369 11.00000 -1.50000 H17B 2 0.042578 1.037328 0.134361 11.00000 -1.50000 H17C 2 0.174038 1.111839 0.143807 11.00000 -1.50000 AFIX 0 C18 1 0.393183 0.966475 0.166429 11.00000 0.02282 0.02550 = 0.02615 0.00205 0.00926 -0.00132 AFIX 137 H18A 2 0.359341 0.946734 0.100187 11.00000 -1.50000 H18B 2 0.484692 0.953324 0.166431 11.00000 -1.50000 H18C 2 0.374486 1.056107 0.183171 11.00000 -1.50000 AFIX 0 C19 1 0.372742 0.739829 0.224260 11.00000 0.01954 0.01964 = 0.02565 -0.00330 0.00264 0.00312 AFIX 137 H19A 2 0.344469 0.713404 0.157790 11.00000 -1.50000 H19B 2 0.334781 0.683602 0.274592 11.00000 -1.50000 H19C 2 0.464823 0.733510 0.228063 11.00000 -1.50000 HKLF 4 REM p11025_11 in P2(1)2(1)2(1) REM R1 = 0.0272 for 2976 Fo > 4sig(Fo) and 0.0276 for all 3015 data REM 193 parameters refined using 0 restraints END WGHT 0.0457 0.1865 REM Highest difference peak 0.226, deepest hole -0.262, 1-sigma level 0.048 Q1 1 0.2652 1.0841 0.3680 11.00000 0.05 0.23 Q2 1 0.2553 0.8909 0.2475 11.00000 0.05 0.18 Q3 1 0.1988 0.9150 0.4111 11.00000 0.05 0.14 Q4 1 0.1735 1.0689 0.3114 11.00000 0.05 0.14 Q5 1 0.2824 0.8889 0.4720 11.00000 0.05 0.13 Q6 1 0.2292 0.9320 0.4585 11.00000 0.05 0.13 Q7 1 -0.0078 1.1337 0.3278 11.00000 0.05 0.13 Q8 1 0.3567 1.1185 0.4138 11.00000 0.05 0.13 Q9 1 0.5758 0.8438 0.3422 11.00000 0.05 0.13 ; loop_ _symmetry_equiv_pos_as_xyz 'x, y, z' '-x+1/2, -y, z+1/2' '-x, y+1/2, -z+1/2' 'x+1/2, -y+1/2, -z' loop_ _atom_site_type_symbol _atom_site_label _atom_site_fract_x _atom_site_fract_y _atom_site_fract_z _atom_site_U_iso_or_equiv _atom_site_adp_type _atom_site_calc_flag _atom_site_refinement_flags _atom_site_occupancy _atom_site_disorder_assembly _atom_site_disorder_group S S1 0.38897(3) 0.91546(3) 0.36886(2) 0.01926(9) Uani d . 1 . . N N1 -0.31310(12) 0.85585(12) 0.49801(10) 0.0248(3) Uani d . 1 . . H H1A -0.3838(19) 0.8461(18) 0.4644(13) 0.025(4) Uiso d . 1 . . H H1B -0.2944(19) 0.788(2) 0.5429(15) 0.035(5) Uiso d . 1 . . C C2 0.33254(12) 0.87819(12) 0.24344(9) 0.0169(2) Uani d . 1 . . C C3 0.18820(11) 0.88597(12) 0.24655(9) 0.0153(2) Uani d . 1 . . H H3A 0.1582 0.8205 0.2945 0.018 Uiso calc R 1 . . H H3B 0.1563 0.8607 0.1800 0.018 Uiso calc R 1 . . C C4 0.12454(11) 1.01631(11) 0.27477(8) 0.0141(2) Uani d . 1 . . C C5 0.20406(11) 1.10235(12) 0.34388(9) 0.0144(2) Uani d . 1 . . C C6 0.15741(12) 1.22434(12) 0.36787(10) 0.0189(2) Uani d . 1 . . H H6A 0.0794 1.2508 0.3397 0.023 Uiso calc R 1 . . C C7 0.22048(13) 1.30817(13) 0.43106(10) 0.0208(3) Uani d . 1 . . H H7A 0.1861 1.3904 0.4452 0.025 Uiso calc R 1 . . C C8 0.33499(13) 1.27065(13) 0.47374(9) 0.0196(2) Uani d . 1 . . H H8A 0.3790 1.3267 0.5175 0.024 Uiso calc R 1 . . C C9 0.38292(12) 1.15119(13) 0.45126(9) 0.0181(2) Uani d . 1 . . H H9A 0.4609 1.1253 0.4797 0.022 Uiso calc R 1 . . C C10 0.31913(11) 1.06723(12) 0.38749(8) 0.0150(2) Uani d . 1 . . C C11 0.00344(12) 0.98106(11) 0.33143(9) 0.0140(2) Uani d . 1 . . C C12 -0.11773(12) 0.99061(11) 0.29291(9) 0.0171(2) Uani d . 1 . . H H12A -0.1297 1.0272 0.2287 0.021 Uiso calc R 1 . . C C13 -0.22232(12) 0.94758(13) 0.34639(10) 0.0192(3) Uani d . 1 . . H H13A -0.3040 0.9547 0.3178 0.023 Uiso calc R 1 . . C C14 -0.20898(11) 0.89450(12) 0.44087(10) 0.0175(2) Uani d . 1 . . C C15 -0.08745(12) 0.88703(12) 0.48142(9) 0.0173(2) Uani d . 1 . . H H15A -0.0758 0.8530 0.5465 0.021 Uiso calc R 1 . . C C16 0.01529(11) 0.92868(12) 0.42750(9) 0.0151(2) Uani d . 1 . . H H16A 0.0969 0.9217 0.4562 0.018 Uiso calc R 1 . . C C17 0.09506(12) 1.09065(13) 0.17800(9) 0.0191(2) Uani d . 1 . . H H17A 0.0498 1.1700 0.1944 0.029 Uiso calc R 1 . . H H17B 0.0426 1.0373 0.1344 0.029 Uiso calc R 1 . . H H17C 0.1740 1.1118 0.1438 0.029 Uiso calc R 1 . . C C18 0.39319(13) 0.96648(10) 0.16643(8) 0.0248(3) Uani d . 1 . . H H18A 0.3593 0.9468 0.1002 0.037 Uiso calc R 1 . . H H18B 0.4847 0.9533 0.1664 0.037 Uiso calc R 1 . . H H18C 0.3745 1.0561 0.1832 0.037 Uiso calc R 1 . . C C19 0.37274(13) 0.73983(13) 0.22426(10) 0.0216(3) Uani d . 1 . . H H19A 0.3445 0.7134 0.1578 0.032 Uiso calc R 1 . . H H19B 0.3348 0.6836 0.2746 0.032 Uiso calc R 1 . . H H19C 0.4648 0.7335 0.2281 0.032 Uiso calc R 1 . . loop_ _atom_site_aniso_label _atom_site_aniso_U_11 _atom_site_aniso_U_22 _atom_site_aniso_U_33 _atom_site_aniso_U_12 _atom_site_aniso_U_13 _atom_site_aniso_U_23 S1 0.01732(14) 0.01801(15) 0.02245(14) 0.00423(11) -0.00470(11) -0.00267(11) N1 0.0178(6) 0.0242(6) 0.0323(6) -0.0056(5) 0.0048(5) 0.0010(5) C2 0.0149(5) 0.0174(6) 0.0182(5) 0.0016(4) 0.0025(4) -0.0015(4) C3 0.0138(5) 0.0152(5) 0.0169(5) 0.0004(4) 0.0001(4) -0.0016(4) C4 0.0142(5) 0.0127(5) 0.0154(5) -0.0002(4) -0.0016(4) 0.0007(4) C5 0.0142(5) 0.0137(5) 0.0153(5) -0.0016(4) 0.0015(4) 0.0013(4) C6 0.0184(6) 0.0152(5) 0.0231(5) 0.0005(5) -0.0014(5) 0.0002(5) C7 0.0225(6) 0.0154(6) 0.0246(6) -0.0016(5) 0.0022(5) -0.0025(5) C8 0.0212(6) 0.0190(6) 0.0187(5) -0.0068(5) 0.0013(5) -0.0015(5) C9 0.0152(5) 0.0224(6) 0.0168(5) -0.0037(5) -0.0009(5) 0.0017(5) C10 0.0148(5) 0.0144(5) 0.0159(5) -0.0011(5) 0.0023(4) 0.0014(4) C11 0.0148(6) 0.0092(5) 0.0180(5) 0.0002(4) 0.0001(4) -0.0017(4) C12 0.0168(6) 0.0144(5) 0.0202(5) 0.0010(5) -0.0034(5) 0.0004(4) C13 0.0137(5) 0.0176(6) 0.0263(6) 0.0014(5) -0.0030(5) -0.0007(5) C14 0.0161(6) 0.0118(6) 0.0247(6) -0.0022(4) 0.0035(5) -0.0031(5) C15 0.0188(6) 0.0143(6) 0.0190(5) 0.0001(4) 0.0001(5) -0.0002(4) C16 0.0149(5) 0.0128(5) 0.0176(5) 0.0000(4) -0.0019(4) -0.0019(5) C17 0.0203(6) 0.0190(6) 0.0180(5) 0.0000(5) -0.0017(4) 0.0037(5) C18 0.0228(6) 0.0255(7) 0.0261(6) -0.0013(6) 0.0093(6) 0.0021(5) C19 0.0195(6) 0.0196(6) 0.0257(6) 0.0031(5) 0.0026(5) -0.0033(5) loop_ _atom_type_symbol _atom_type_description _atom_type_scat_dispersion_real _atom_type_scat_dispersion_imag _atom_type_scat_source C C 0.0181 0.0091 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' N N 0.0311 0.0180 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' S S 0.3331 0.5567 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' loop_ _geom_angle_atom_site_label_1 _geom_angle_atom_site_label_2 _geom_angle_atom_site_label_3 _geom_angle_site_symmetry_1 _geom_angle_site_symmetry_3 _geom_angle _geom_angle_publ_flag C10 S1 C2 . . 100.56(6) ? C14 N1 H1A . . 115.1(12) ? C14 N1 H1B . . 113.3(12) ? H1A N1 H1B . . 114.7(17) ? C19 C2 C18 . . 109.71(10) ? C19 C2 C3 . . 109.49(10) ? C18 C2 C3 . . 114.05(11) ? C19 C2 S1 . . 105.34(9) ? C18 C2 S1 . . 110.95(9) ? C3 C2 S1 . . 106.90(8) ? C2 C3 C4 . . 118.93(10) ? C2 C3 H3A . . 107.6 ? C4 C3 H3A . . 107.6 ? C2 C3 H3B . . 107.6 ? C4 C3 H3B . . 107.6 ? H3A C3 H3B . . 107.0 ? C11 C4 C5 . . 107.38(9) ? C11 C4 C17 . . 111.50(10) ? C5 C4 C17 . . 109.00(10) ? C11 C4 C3 . . 105.87(9) ? C5 C4 C3 . . 114.48(10) ? C17 C4 C3 . . 108.62(10) ? C6 C5 C10 . . 116.63(11) ? C6 C5 C4 . . 118.18(10) ? C10 C5 C4 . . 125.17(11) ? C7 C6 C5 . . 122.70(12) ? C7 C6 H6A . . 118.7 ? C5 C6 H6A . . 118.7 ? C6 C7 C8 . . 119.52(13) ? C6 C7 H7A . . 120.2 ? C8 C7 H7A . . 120.2 ? C9 C8 C7 . . 118.90(12) ? C9 C8 H8A . . 120.5 ? C7 C8 H8A . . 120.5 ? C8 C9 C10 . . 121.34(12) ? C8 C9 H9A . . 119.3 ? C10 C9 H9A . . 119.3 ? C9 C10 C5 . . 120.91(12) ? C9 C10 S1 . . 116.35(10) ? C5 C10 S1 . . 122.71(10) ? C12 C11 C16 . . 116.87(11) ? C12 C11 C4 . . 124.90(11) ? C16 C11 C4 . . 118.14(10) ? C11 C12 C13 . . 121.43(11) ? C11 C12 H12A . . 119.3 ? C13 C12 H12A . . 119.3 ? C14 C13 C12 . . 121.05(11) ? C14 C13 H13A . . 119.5 ? C12 C13 H13A . . 119.5 ? C13 C14 C15 . . 118.01(11) ? C13 C14 N1 . . 122.15(12) ? C15 C14 N1 . . 119.73(12) ? C16 C15 C14 . . 120.41(11) ? C16 C15 H15A . . 119.8 ? C14 C15 H15A . . 119.8 ? C15 C16 C11 . . 122.20(11) ? C15 C16 H16A . . 118.9 ? C11 C16 H16A . . 118.9 ? C4 C17 H17A . . 109.5 ? C4 C17 H17B . . 109.5 ? H17A C17 H17B . . 109.5 ? C4 C17 H17C . . 109.5 ? H17A C17 H17C . . 109.5 ? H17B C17 H17C . . 109.5 ? C2 C18 H18A . . 109.5 ? C2 C18 H18B . . 109.5 ? H18A C18 H18B . . 109.5 ? C2 C18 H18C . . 109.5 ? H18A C18 H18C . . 109.5 ? H18B C18 H18C . . 109.5 ? C2 C19 H19A . . 109.5 ? C2 C19 H19B . . 109.5 ? H19A C19 H19B . . 109.5 ? C2 C19 H19C . . 109.5 ? H19A C19 H19C . . 109.5 ? H19B C19 H19C . . 109.5 ? loop_ _geom_bond_atom_site_label_1 _geom_bond_atom_site_label_2 _geom_bond_site_symmetry_2 _geom_bond_distance _geom_bond_publ_flag S1 C10 . 1.7627(13) ? S1 C2 . 1.8271(13) ? N1 C14 . 1.4030(16) ? N1 H1A . 0.88(2) ? N1 H1B . 0.95(2) ? C2 C19 . 1.5240(17) ? C2 C18 . 1.5249(17) ? C2 C3 . 1.5334(17) ? C3 C4 . 1.5622(16) ? C3 H3A . 0.9900 ? C3 H3B . 0.9900 ? C4 C11 . 1.5367(16) ? C4 C5 . 1.5403(16) ? C4 C17 . 1.5432(15) ? C5 C6 . 1.4004(17) ? C5 C10 . 1.4017(17) ? C6 C7 . 1.3883(19) ? C6 H6A . 0.9500 ? C7 C8 . 1.398(2) ? C7 H7A . 0.9500 ? C8 C9 . 1.3770(19) ? C8 H8A . 0.9500 ? C9 C10 . 1.3975(17) ? C9 H9A . 0.9500 ? C11 C12 . 1.3885(17) ? C11 C16 . 1.4047(17) ? C12 C13 . 1.3947(18) ? C12 H12A . 0.9500 ? C13 C14 . 1.3897(19) ? C13 H13A . 0.9500 ? C14 C15 . 1.4010(17) ? C15 C16 . 1.3777(18) ? C15 H15A . 0.9500 ? C16 H16A . 0.9500 ? C17 H17A . 0.9800 ? C17 H17B . 0.9800 ? C17 H17C . 0.9800 ? C18 H18A . 0.9800 ? C18 H18B . 0.9800 ? C18 H18C . 0.9800 ? C19 H19A . 0.9800 ? C19 H19B . 0.9800 ? C19 H19C . 0.9800 ? loop_ _geom_hbond_atom_site_label_D _geom_hbond_atom_site_label_H _geom_hbond_atom_site_label_A _geom_hbond_site_symmetry_A _geom_hbond_distance_DH _geom_hbond_distance_HA _geom_hbond_distance_DA _geom_hbond_angle_DHA _geom_hbond_publ_flag N1 H1A S1 1_455 0.88(2) 2.82(2) 3.6562(14) 158.3(16) y loop_ _geom_torsion_atom_site_label_1 _geom_torsion_atom_site_label_2 _geom_torsion_atom_site_label_3 _geom_torsion_atom_site_label_4 _geom_torsion_site_symmetry_1 _geom_torsion_site_symmetry_2 _geom_torsion_site_symmetry_3 _geom_torsion_site_symmetry_4 _geom_torsion _geom_torsion_publ_flag C10 S1 C2 C19 . . . . -172.58(8) ? C10 S1 C2 C18 . . . . 68.76(10) ? C10 S1 C2 C3 . . . . -56.16(9) ? C19 C2 C3 C4 . . . . 174.57(10) ? C18 C2 C3 C4 . . . . -62.07(14) ? S1 C2 C3 C4 . . . . 60.94(12) ? C2 C3 C4 C11 . . . . -146.59(11) ? C2 C3 C4 C5 . . . . -28.51(15) ? C2 C3 C4 C17 . . . . 93.55(12) ? C11 C4 C5 C6 . . . . -66.66(13) ? C17 C4 C5 C6 . . . . 54.26(14) ? C3 C4 C5 C6 . . . . 176.12(10) ? C11 C4 C5 C10 . . . . 111.56(13) ? C17 C4 C5 C10 . . . . -127.51(12) ? C3 C4 C5 C10 . . . . -5.66(16) ? C10 C5 C6 C7 . . . . 0.29(18) ? C4 C5 C6 C7 . . . . 178.67(12) ? C5 C6 C7 C8 . . . . -0.4(2) ? C6 C7 C8 C9 . . . . 0.46(19) ? C7 C8 C9 C10 . . . . -0.38(19) ? C8 C9 C10 C5 . . . . 0.26(18) ? C8 C9 C10 S1 . . . . -177.90(9) ? C6 C5 C10 C9 . . . . -0.20(16) ? C4 C5 C10 C9 . . . . -178.45(11) ? C6 C5 C10 S1 . . . . 177.84(9) ? C4 C5 C10 S1 . . . . -0.41(16) ? C2 S1 C10 C9 . . . . -151.41(9) ? C2 S1 C10 C5 . . . . 30.47(11) ? C5 C4 C11 C12 . . . . 131.44(12) ? C17 C4 C11 C12 . . . . 12.11(17) ? C3 C4 C11 C12 . . . . -105.85(13) ? C5 C4 C11 C16 . . . . -52.17(14) ? C17 C4 C11 C16 . . . . -171.50(10) ? C3 C4 C11 C16 . . . . 70.54(13) ? C16 C11 C12 C13 . . . . -1.34(18) ? C4 C11 C12 C13 . . . . 175.09(12) ? C11 C12 C13 C14 . . . . 0.6(2) ? C12 C13 C14 C15 . . . . 0.84(19) ? C12 C13 C14 N1 . . . . 177.07(12) ? C13 C14 C15 C16 . . . . -1.47(19) ? N1 C14 C15 C16 . . . . -177.79(12) ? C14 C15 C16 C11 . . . . 0.72(18) ? C12 C11 C16 C15 . . . . 0.69(18) ? C4 C11 C16 C15 . . . . -175.99(12) ? _cod_database_fobs_code 2018056