#------------------------------------------------------------------------------ #$Date: 2017-12-23 07:13:23 +0200 (Sat, 23 Dec 2017) $ #$Revision: 204511 $ #$URL: file:///home/coder/svn-repositories/cod/cif/7/15/60/7156037.cif $ #------------------------------------------------------------------------------ # # This file is available in the Crystallography Open Database (COD), # http://www.crystallography.net/ # # All data on this site have been placed in the public domain by the # contributors. # data_7156037 loop_ _publ_author_name 'Milyutina, Maria' 'Janke, Julia' 'Hassan, Sidra' 'Zaib, Sumera' 'Iqbal, Jamshed' 'Lecka, Joanna' 'Sevigny, Jean' 'Villinger, Alexander' 'Friedrich, Aleksej' 'Lochbrunner, Stefan' 'Langer, Peter' _publ_section_title ; Domino Reaction of 3-Chlorochromones with Aminoheterocycles. Synthesis of Pyrazolopyridines and Benzofuropyridines and their Optical and Ecto-5'-nucleotidase Inhibitory Effects ; _journal_name_full 'Organic & Biomolecular Chemistry' _journal_paper_doi 10.1039/C7OB02729J _journal_year 2017 _chemical_formula_moiety 'C14 H10 Cl N3 O3, C2 H6 O S' _chemical_formula_sum 'C16 H16 Cl N3 O4 S' _chemical_formula_weight 381.83 _chemical_name_systematic 6-Chloro-7-(2-hydroxy-5-methylphenyl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione _space_group_crystal_system triclinic _space_group_IT_number 2 _space_group_name_Hall '-P 1' _space_group_name_H-M_alt 'P -1' _symmetry_space_group_name_Hall '-P 1' _symmetry_space_group_name_H-M 'P -1' _atom_sites_solution_hydrogens mixed _audit_creation_method SHELXL-2013 _audit_update_record ; 2017-06-02 deposited with the CCDC. 2017-12-22 downloaded from the CCDC. ; _cell_angle_alpha 78.2630(10) _cell_angle_beta 86.7750(10) _cell_angle_gamma 76.9220(10) _cell_formula_units_Z 2 _cell_length_a 7.2883(2) _cell_length_b 7.8141(2) _cell_length_c 15.5616(3) _cell_measurement_reflns_used 9901 _cell_measurement_temperature 173(2) _cell_measurement_theta_max 32.07 _cell_measurement_theta_min 2.73 _cell_volume 845.17(4) _computing_cell_refinement 'Bruker Apex V7.51A' _computing_data_collection 'Bruker Apex V7.51A' _computing_data_reduction 'Bruker SAINT' _computing_molecular_graphics 'ORTEP-3v2.01 (Farrugia, 1997)' _computing_publication_material SHELXL-2013 _computing_structure_refinement 'SHELXL-2013 (Sheldrick, 2013)' _computing_structure_solution 'SHELXS-2013 (Sheldrick, 2013)' _diffrn_ambient_temperature 173(2) _diffrn_measured_fraction_theta_full 0.998 _diffrn_measured_fraction_theta_max 0.990 _diffrn_measurement_device_type 'Bruker-Nonius Apex X8-CCD-diffractometer' _diffrn_measurement_method 'phi and omega scans' _diffrn_radiation_monochromator graphite _diffrn_radiation_source 'sealed tube' _diffrn_radiation_type MoK\a _diffrn_radiation_wavelength 0.71073 _diffrn_reflns_av_R_equivalents 0.0233 _diffrn_reflns_av_unetI/netI 0.0302 _diffrn_reflns_Laue_measured_fraction_full 0.998 _diffrn_reflns_Laue_measured_fraction_max 0.990 _diffrn_reflns_limit_h_max 11 _diffrn_reflns_limit_h_min -10 _diffrn_reflns_limit_k_max 11 _diffrn_reflns_limit_k_min -11 _diffrn_reflns_limit_l_max 23 _diffrn_reflns_limit_l_min -23 _diffrn_reflns_number 27106 _diffrn_reflns_point_group_measured_fraction_full 0.998 _diffrn_reflns_point_group_measured_fraction_max 0.990 _diffrn_reflns_theta_full 25.242 _diffrn_reflns_theta_max 32.500 _diffrn_reflns_theta_min 2.674 _exptl_absorpt_coefficient_mu 0.377 _exptl_absorpt_correction_T_max 0.7464 _exptl_absorpt_correction_T_min 0.6974 _exptl_absorpt_correction_type multi-scan _exptl_absorpt_process_details '(SADABS; Sheldrick, 2004)' _exptl_crystal_colour colourless _exptl_crystal_density_diffrn 1.500 _exptl_crystal_description block _exptl_crystal_F_000 396 _exptl_crystal_size_max 0.290 _exptl_crystal_size_mid 0.230 _exptl_crystal_size_min 0.060 _refine_diff_density_max 0.531 _refine_diff_density_min -0.351 _refine_diff_density_rms 0.066 _refine_ls_extinction_method none _refine_ls_goodness_of_fit_ref 1.039 _refine_ls_hydrogen_treatment mixed _refine_ls_matrix_type full _refine_ls_number_parameters 241 _refine_ls_number_reflns 6050 _refine_ls_number_restraints 0 _refine_ls_restrained_S_all 1.039 _refine_ls_R_factor_all 0.0550 _refine_ls_R_factor_gt 0.0390 _refine_ls_shift/su_max 0.000 _refine_ls_shift/su_mean 0.000 _refine_ls_structure_factor_coef Fsqd _refine_ls_weighting_details 'w=1/[\s^2^(Fo^2^)+(0.0489P)^2^+0.3361P] where P=(Fo^2^+2Fc^2^)/3' _refine_ls_weighting_scheme calc _refine_ls_wR_factor_gt 0.0941 _refine_ls_wR_factor_ref 0.1038 _reflns_Friedel_coverage 0.000 _reflns_number_gt 4834 _reflns_number_total 6050 _reflns_threshold_expression 'I > 2\s(I)' _cod_data_source_file c7ob02729j2.cif _cod_data_source_block is_mm258 _cod_database_code 7156037 _shelx_space_group_comment ; The symmetry employed for this shelxl refinement is uniquely defined by the following loop, which should always be used as a source of symmetry information in preference to the above space-group names. They are only intended as comments. ; _shelx_estimated_absorpt_t_min 0.899 _shelx_estimated_absorpt_t_max 0.978 _shelxl_version_number 2013-4 _shelx_res_file ; TITL mm258 in P-1 CELL 0.71073 7.2883 7.8141 15.5616 78.263 86.775 76.922 ZERR 2.00 0.0002 0.0002 0.0003 0.001 0.001 0.001 LATT 1 SFAC C H N O CL S UNIT 32 32 6 8 2 2 MERG 2 OMIT -3.00 65.00 OMIT 0 0 1 OMIT 1 0 0 OMIT 0 -1 7 FMAP 2 PLAN 10 SIZE 0.060 0.230 0.290 ACTA BOND $H CONF L.S. 8 TEMP -100.00 WGHT 0.048900 0.336100 FVAR 0.28773 MOLE 1 CL1 5 0.928168 -0.012705 0.148599 11.00000 0.04272 0.01440 = 0.01907 -0.00225 -0.00246 0.00603 N1 3 0.772586 0.517680 0.126786 11.00000 0.02209 0.01456 = 0.01235 -0.00198 0.00028 -0.00369 N2 3 0.663276 0.749205 0.010100 11.00000 0.03258 0.01293 = 0.01193 -0.00216 -0.00143 -0.00348 N3 3 0.622005 0.697704 -0.129438 11.00000 0.02553 0.01565 = 0.01115 -0.00155 -0.00066 -0.00238 O1 4 0.535749 0.978032 -0.100591 11.00000 0.04617 0.01480 = 0.01675 -0.00001 -0.00136 -0.00008 O2 4 0.693045 0.418476 -0.160596 11.00000 0.03533 0.01989 = 0.01466 -0.00592 -0.00003 -0.00684 O3 4 0.604939 0.153026 0.282208 11.00000 0.02513 0.02416 = 0.01549 0.00048 -0.00312 -0.01052 C1 1 0.828481 0.341741 0.160141 11.00000 0.01749 0.01531 = 0.01281 -0.00202 0.00128 -0.00282 C2 1 0.848995 0.213116 0.106532 11.00000 0.02165 0.01306 = 0.01449 -0.00174 0.00179 0.00042 C3 1 0.808293 0.266408 0.018168 11.00000 0.02228 0.01600 = 0.01335 -0.00451 0.00278 -0.00128 AFIX 43 H3A 2 0.823450 0.181003 -0.018722 11.00000 -1.20000 AFIX 0 C4 1 0.744558 0.448292 -0.015402 11.00000 0.01900 0.01516 = 0.01085 -0.00206 0.00163 -0.00291 C5 1 0.729948 0.567770 0.041447 11.00000 0.01880 0.01339 = 0.01215 -0.00142 0.00103 -0.00361 C6 1 0.687121 0.514163 -0.107088 11.00000 0.01932 0.01662 = 0.01265 -0.00267 0.00295 -0.00541 C7 1 0.602922 0.818599 -0.074185 11.00000 0.02664 0.01519 = 0.01302 -0.00186 0.00101 -0.00412 C8 1 0.866694 0.292891 0.256080 11.00000 0.02007 0.01352 = 0.01087 -0.00162 0.00045 -0.00098 C9 1 1.012198 0.349366 0.289307 11.00000 0.01955 0.01577 = 0.01577 -0.00252 0.00266 -0.00360 AFIX 43 H9 2 1.085744 0.416891 0.249810 11.00000 -1.20000 AFIX 0 C10 1 1.052722 0.309837 0.378360 11.00000 0.02106 0.01596 = 0.01794 -0.00369 -0.00228 -0.00307 C11 1 0.937451 0.215852 0.434763 11.00000 0.02757 0.01998 = 0.01264 -0.00128 -0.00268 -0.00569 AFIX 43 H11 2 0.961522 0.188034 0.495968 11.00000 -1.20000 AFIX 0 C12 1 0.788691 0.161796 0.404125 11.00000 0.02584 0.02014 = 0.01284 -0.00084 0.00020 -0.00704 AFIX 43 H12 2 0.711584 0.099349 0.444121 11.00000 -1.20000 AFIX 0 C13 1 0.752966 0.199781 0.314048 11.00000 0.01951 0.01410 = 0.01349 -0.00211 -0.00095 -0.00256 C14 1 1.214622 0.364823 0.413454 11.00000 0.03038 0.02841 = 0.02702 -0.00590 -0.00509 -0.01160 AFIX 137 H14A 2 1.297426 0.401816 0.364758 11.00000 -1.50000 H14B 2 1.285948 0.263352 0.455047 11.00000 -1.50000 H14C 2 1.165738 0.465045 0.443371 11.00000 -1.50000 AFIX 0 H1 2 0.568254 0.741031 -0.181031 11.00000 0.02662 H2 2 0.632188 0.823353 0.048707 11.00000 0.03425 H3 2 0.559647 0.085676 0.320090 11.00000 0.03927 MOLE 2 S1 6 0.426765 0.766692 0.382458 11.00000 0.02831 0.01762 = 0.01895 -0.00286 -0.00124 -0.00682 O4 4 0.479661 0.929297 0.404014 11.00000 0.04337 0.02796 = 0.01970 -0.00636 0.00209 -0.02036 C15 1 0.240801 0.852655 0.305412 11.00000 0.03198 0.02960 = 0.03155 -0.00915 -0.00826 -0.00214 AFIX 137 H15A 2 0.132540 0.921815 0.332880 11.00000 -1.50000 H15B 2 0.203793 0.753064 0.286616 11.00000 -1.50000 H15C 2 0.283692 0.930411 0.254325 11.00000 -1.50000 AFIX 0 C16 1 0.602465 0.682452 0.308466 11.00000 0.03660 0.04190 = 0.05335 -0.02299 0.00711 0.00442 AFIX 137 H16A 2 0.621399 0.780742 0.260990 11.00000 -1.50000 H16B 2 0.561953 0.591432 0.283732 11.00000 -1.50000 H16C 2 0.720906 0.628743 0.339884 11.00000 -1.50000 AFIX 0 HKLF 4 REM mm258 in P-1 REM R1 = 0.0390 for 4834 Fo > 4sig(Fo) and 0.0550 for all 6050 data REM 241 parameters refined using 0 restraints END WGHT 0.0489 0.3361 REM Highest difference peak 0.531, deepest hole -0.351, 1-sigma level 0.066 Q1 1 0.8460 0.3183 0.2116 11.00000 0.05 0.53 Q2 1 0.8117 0.2405 0.0666 11.00000 0.05 0.53 Q3 1 0.7920 0.1685 0.3571 11.00000 0.05 0.52 Q4 1 0.6259 0.7753 -0.0299 11.00000 0.05 0.50 Q5 1 0.7090 0.4755 -0.0573 11.00000 0.05 0.50 Q6 1 0.9999 0.2551 0.4078 11.00000 0.05 0.49 Q7 1 1.0226 0.0194 0.1384 11.00000 0.05 0.49 Q8 1 0.8000 0.2543 0.2871 11.00000 0.05 0.46 Q9 1 1.0257 0.3372 0.3339 11.00000 0.05 0.45 Q10 1 0.7549 0.5339 0.0843 11.00000 0.05 0.43 ; _shelx_res_checksum 53544 loop_ _space_group_symop_operation_xyz 'x, y, z' '-x, -y, -z' loop_ _atom_site_label _atom_site_type_symbol _atom_site_fract_x _atom_site_fract_y _atom_site_fract_z _atom_site_U_iso_or_equiv _atom_site_adp_type _atom_site_occupancy _atom_site_site_symmetry_order _atom_site_calc_flag _atom_site_refinement_flags_posn _atom_site_refinement_flags_adp Cl1 Cl 0.92817(6) -0.01270(4) 0.14860(2) 0.02746(9) Uani 1 1 d . . N1 N 0.77259(16) 0.51768(13) 0.12679(6) 0.0165(2) Uani 1 1 d . . N2 N 0.66328(18) 0.74921(14) 0.01010(7) 0.0194(2) Uani 1 1 d . . N3 N 0.62200(17) 0.69770(14) -0.12944(7) 0.0179(2) Uani 1 1 d . . O1 O 0.53575(17) 0.97803(12) -0.10059(6) 0.0274(2) Uani 1 1 d . . O2 O 0.69305(15) 0.41848(12) -0.16060(6) 0.0228(2) Uani 1 1 d . . O3 O 0.60494(15) 0.15303(13) 0.28221(6) 0.02128(19) Uani 1 1 d . . C1 C 0.82848(18) 0.34174(15) 0.16014(7) 0.0155(2) Uani 1 1 d . . C2 C 0.84899(19) 0.21312(16) 0.10653(8) 0.0173(2) Uani 1 1 d . . C3 C 0.80829(19) 0.26641(16) 0.01817(8) 0.0176(2) Uani 1 1 d . . H3A H 0.8235 0.1810 -0.0187 0.021 Uiso 1 1 calc R U C4 C 0.74456(18) 0.44829(15) -0.01540(7) 0.0153(2) Uani 1 1 d . . C5 C 0.72995(18) 0.56777(15) 0.04145(7) 0.0150(2) Uani 1 1 d . . C6 C 0.68712(18) 0.51416(16) -0.10709(8) 0.0161(2) Uani 1 1 d . . C7 C 0.6029(2) 0.81860(16) -0.07419(8) 0.0185(2) Uani 1 1 d . . C8 C 0.86669(18) 0.29289(15) 0.25608(7) 0.0154(2) Uani 1 1 d . . C9 C 1.01220(18) 0.34937(16) 0.28931(8) 0.0173(2) Uani 1 1 d . . H9 H 1.0857 0.4169 0.2498 0.021 Uiso 1 1 calc R U C10 C 1.05272(19) 0.30984(16) 0.37836(8) 0.0183(2) Uani 1 1 d . . C11 C 0.9375(2) 0.21585(17) 0.43476(8) 0.0202(2) Uani 1 1 d . . H11 H 0.9615 0.1880 0.4960 0.024 Uiso 1 1 calc R U C12 C 0.7887(2) 0.16180(17) 0.40413(8) 0.0196(2) Uani 1 1 d . . H12 H 0.7116 0.0993 0.4441 0.024 Uiso 1 1 calc R U C13 C 0.75297(18) 0.19978(15) 0.31405(8) 0.0159(2) Uani 1 1 d . . C14 C 1.2146(2) 0.3648(2) 0.41345(10) 0.0275(3) Uani 1 1 d . . H14A H 1.2974 0.4018 0.3648 0.041 Uiso 1 1 calc R U H14B H 1.2859 0.2634 0.4550 0.041 Uiso 1 1 calc R U H14C H 1.1657 0.4650 0.4434 0.041 Uiso 1 1 calc R U H1 H 0.568(3) 0.741(2) -0.1810(12) 0.027(4) Uiso 1 1 d . . H2 H 0.632(3) 0.823(3) 0.0487(13) 0.034(5) Uiso 1 1 d . . H3 H 0.560(3) 0.086(3) 0.3201(14) 0.039(5) Uiso 1 1 d . . S1 S 0.42676(5) 0.76669(4) 0.38246(2) 0.02141(8) Uani 1 1 d . . O4 O 0.47966(17) 0.92930(14) 0.40401(6) 0.0282(2) Uani 1 1 d . . C15 C 0.2408(2) 0.8527(2) 0.30541(11) 0.0310(3) Uani 1 1 d . . H15A H 0.1325 0.9218 0.3329 0.047 Uiso 1 1 calc R U H15B H 0.2038 0.7531 0.2866 0.047 Uiso 1 1 calc R U H15C H 0.2837 0.9304 0.2543 0.047 Uiso 1 1 calc R U C16 C 0.6025(3) 0.6825(3) 0.30847(14) 0.0444(4) Uani 1 1 d . . H16A H 0.6214 0.7807 0.2610 0.067 Uiso 1 1 calc R U H16B H 0.5620 0.5914 0.2837 0.067 Uiso 1 1 calc R U H16C H 0.7209 0.6287 0.3399 0.067 Uiso 1 1 calc R U loop_ _atom_site_aniso_label _atom_site_aniso_U_11 _atom_site_aniso_U_22 _atom_site_aniso_U_33 _atom_site_aniso_U_23 _atom_site_aniso_U_13 _atom_site_aniso_U_12 Cl1 0.0427(2) 0.01440(13) 0.01907(14) -0.00225(10) -0.00246(13) 0.00603(12) N1 0.0221(5) 0.0146(4) 0.0123(4) -0.0020(3) 0.0003(4) -0.0037(4) N2 0.0326(6) 0.0129(4) 0.0119(4) -0.0022(3) -0.0014(4) -0.0035(4) N3 0.0255(6) 0.0156(4) 0.0111(4) -0.0016(3) -0.0007(4) -0.0024(4) O1 0.0462(7) 0.0148(4) 0.0168(4) 0.0000(3) -0.0014(4) -0.0001(4) O2 0.0353(6) 0.0199(4) 0.0147(4) -0.0059(3) 0.0000(4) -0.0068(4) O3 0.0251(5) 0.0242(4) 0.0155(4) 0.0005(3) -0.0031(4) -0.0105(4) C1 0.0175(6) 0.0153(5) 0.0128(5) -0.0020(4) 0.0013(4) -0.0028(4) C2 0.0216(6) 0.0131(5) 0.0145(5) -0.0017(4) 0.0018(4) 0.0004(4) C3 0.0223(6) 0.0160(5) 0.0134(5) -0.0045(4) 0.0028(4) -0.0013(4) C4 0.0190(6) 0.0152(5) 0.0109(4) -0.0021(4) 0.0016(4) -0.0029(4) C5 0.0188(6) 0.0134(5) 0.0121(5) -0.0014(4) 0.0010(4) -0.0036(4) C6 0.0193(6) 0.0166(5) 0.0126(5) -0.0027(4) 0.0029(4) -0.0054(4) C7 0.0266(7) 0.0152(5) 0.0130(5) -0.0019(4) 0.0010(4) -0.0041(5) C8 0.0201(6) 0.0135(5) 0.0109(4) -0.0016(4) 0.0004(4) -0.0010(4) C9 0.0196(6) 0.0158(5) 0.0158(5) -0.0025(4) 0.0027(4) -0.0036(4) C10 0.0211(6) 0.0160(5) 0.0179(5) -0.0037(4) -0.0023(5) -0.0031(4) C11 0.0276(7) 0.0200(5) 0.0126(5) -0.0013(4) -0.0027(5) -0.0057(5) C12 0.0258(7) 0.0201(5) 0.0128(5) -0.0008(4) 0.0002(4) -0.0070(5) C13 0.0195(6) 0.0141(5) 0.0135(5) -0.0021(4) -0.0009(4) -0.0026(4) C14 0.0304(8) 0.0284(7) 0.0270(7) -0.0059(5) -0.0051(6) -0.0116(6) S1 0.02831(18) 0.01762(14) 0.01895(15) -0.00286(11) -0.00124(12) -0.00682(12) O4 0.0434(7) 0.0280(5) 0.0197(4) -0.0064(4) 0.0021(4) -0.0204(5) C15 0.0320(8) 0.0296(7) 0.0315(7) -0.0092(6) -0.0083(6) -0.0021(6) C16 0.0366(10) 0.0419(10) 0.0534(11) -0.0230(8) 0.0071(8) 0.0044(8) loop_ _atom_type_symbol _atom_type_description _atom_type_scat_dispersion_real _atom_type_scat_dispersion_imag _atom_type_scat_source C C 0.0033 0.0016 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' N N 0.0061 0.0033 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' O O 0.0106 0.0060 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' Cl Cl 0.1484 0.1585 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' S S 0.1246 0.1234 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' loop_ _geom_angle_atom_site_label_1 _geom_angle_atom_site_label_2 _geom_angle_atom_site_label_3 _geom_angle C5 N1 C1 118.12(10) C7 N2 C5 123.16(10) C7 N2 H2 116.2(12) C5 N2 H2 119.1(12) C7 N3 C6 126.62(10) C7 N3 H1 115.2(12) C6 N3 H1 117.3(12) C13 O3 H3 110.8(14) N1 C1 C2 121.26(10) N1 C1 C8 115.95(10) C2 C1 C8 122.79(10) C3 C2 C1 120.16(11) C3 C2 Cl1 118.51(9) C1 C2 Cl1 121.33(9) C2 C3 C4 118.31(11) C2 C3 H3A 120.8 C4 C3 H3A 120.8 C3 C4 C5 118.25(10) C3 C4 C6 121.50(10) C5 C4 C6 120.21(10) N1 C5 N2 116.73(10) N1 C5 C4 123.85(11) N2 C5 C4 119.40(10) O2 C6 N3 121.35(11) O2 C6 C4 124.28(11) N3 C6 C4 114.37(10) O1 C7 N2 123.05(11) O1 C7 N3 120.81(11) N2 C7 N3 116.14(11) C13 C8 C9 119.35(11) C13 C8 C1 121.03(11) C9 C8 C1 119.53(11) C10 C9 C8 122.08(11) C10 C9 H9 119.0 C8 C9 H9 119.0 C9 C10 C11 117.34(12) C9 C10 C14 121.87(12) C11 C10 C14 120.80(12) C12 C11 C10 122.01(11) C12 C11 H11 119.0 C10 C11 H11 119.0 C11 C12 C13 119.66(12) C11 C12 H12 120.2 C13 C12 H12 120.2 O3 C13 C8 119.39(10) O3 C13 C12 121.04(11) C8 C13 C12 119.53(11) C10 C14 H14A 109.5 C10 C14 H14B 109.5 H14A C14 H14B 109.5 C10 C14 H14C 109.5 H14A C14 H14C 109.5 H14B C14 H14C 109.5 O4 S1 C16 106.46(8) O4 S1 C15 105.47(7) C16 S1 C15 97.19(9) S1 C15 H15A 109.5 S1 C15 H15B 109.5 H15A C15 H15B 109.5 S1 C15 H15C 109.5 H15A C15 H15C 109.5 H15B C15 H15C 109.5 S1 C16 H16A 109.5 S1 C16 H16B 109.5 H16A C16 H16B 109.5 S1 C16 H16C 109.5 H16A C16 H16C 109.5 H16B C16 H16C 109.5 loop_ _geom_bond_atom_site_label_1 _geom_bond_atom_site_label_2 _geom_bond_distance Cl1 C2 1.7283(12) N1 C5 1.3391(15) N1 C1 1.3437(15) N2 C7 1.3695(15) N2 C5 1.3848(15) N2 H2 0.90(2) N3 C7 1.3815(16) N3 C6 1.3823(16) N3 H1 0.882(18) O1 C7 1.2243(15) O2 C6 1.2202(14) O3 C13 1.3620(15) O3 H3 0.81(2) C1 C2 1.4098(17) C1 C8 1.4896(16) C2 C3 1.3818(17) C3 C4 1.3911(16) C3 H3A 0.9500 C4 C5 1.3950(16) C4 C6 1.4652(16) C8 C13 1.3971(17) C8 C9 1.3975(18) C9 C10 1.3906(17) C9 H9 0.9500 C10 C11 1.3963(18) C10 C14 1.5075(19) C11 C12 1.3887(18) C11 H11 0.9500 C12 C13 1.3992(16) C12 H12 0.9500 C14 H14A 0.9800 C14 H14B 0.9800 C14 H14C 0.9800 S1 O4 1.5117(10) S1 C16 1.7776(19) S1 C15 1.7801(15) C15 H15A 0.9800 C15 H15B 0.9800 C15 H15C 0.9800 C16 H16A 0.9800 C16 H16B 0.9800 C16 H16C 0.9800 loop_ _geom_torsion_atom_site_label_1 _geom_torsion_atom_site_label_2 _geom_torsion_atom_site_label_3 _geom_torsion_atom_site_label_4 _geom_torsion C5 N1 C1 C2 2.41(19) C5 N1 C1 C8 -177.61(11) N1 C1 C2 C3 -1.2(2) C8 C1 C2 C3 178.87(12) N1 C1 C2 Cl1 177.88(10) C8 C1 C2 Cl1 -2.09(18) C1 C2 C3 C4 -1.0(2) Cl1 C2 C3 C4 179.98(10) C2 C3 C4 C5 1.70(19) C2 C3 C4 C6 -176.06(12) C1 N1 C5 N2 176.67(11) C1 N1 C5 C4 -1.64(19) C7 N2 C5 N1 -175.73(12) C7 N2 C5 C4 2.7(2) C3 C4 C5 N1 -0.4(2) C6 C4 C5 N1 177.35(12) C3 C4 C5 N2 -178.71(12) C6 C4 C5 N2 -0.92(18) C7 N3 C6 O2 177.72(13) C7 N3 C6 C4 -1.70(19) C3 C4 C6 O2 -1.3(2) C5 C4 C6 O2 -178.97(13) C3 C4 C6 N3 178.15(12) C5 C4 C6 N3 0.43(17) C5 N2 C7 O1 176.44(13) C5 N2 C7 N3 -3.7(2) C6 N3 C7 O1 -176.82(13) C6 N3 C7 N2 3.3(2) N1 C1 C8 C13 113.01(13) C2 C1 C8 C13 -67.01(17) N1 C1 C8 C9 -63.49(16) C2 C1 C8 C9 116.49(14) C13 C8 C9 C10 2.57(19) C1 C8 C9 C10 179.13(11) C8 C9 C10 C11 -2.21(19) C8 C9 C10 C14 177.56(12) C9 C10 C11 C12 0.5(2) C14 C10 C11 C12 -179.27(13) C10 C11 C12 C13 0.8(2) C9 C8 C13 O3 176.53(11) C1 C8 C13 O3 0.02(18) C9 C8 C13 C12 -1.16(18) C1 C8 C13 C12 -177.67(11) C11 C12 C13 O3 -178.12(12) C11 C12 C13 C8 -0.47(19)