#------------------------------------------------------------------------------ #$Date: 2017-12-23 07:13:23 +0200 (Sat, 23 Dec 2017) $ #$Revision: 204511 $ #$URL: file:///home/coder/svn-repositories/cod/cif/7/15/60/7156038.cif $ #------------------------------------------------------------------------------ # # This file is available in the Crystallography Open Database (COD), # http://www.crystallography.net/ # # All data on this site have been placed in the public domain by the # contributors. # data_7156038 loop_ _publ_author_name 'Milyutina, Maria' 'Janke, Julia' 'Hassan, Sidra' 'Zaib, Sumera' 'Iqbal, Jamshed' 'Lecka, Joanna' 'Sevigny, Jean' 'Villinger, Alexander' 'Friedrich, Aleksej' 'Lochbrunner, Stefan' 'Langer, Peter' _publ_section_title ; Domino Reaction of 3-Chlorochromones with Aminoheterocycles. Synthesis of Pyrazolopyridines and Benzofuropyridines and their Optical and Ecto-5'-nucleotidase Inhibitory Effects ; _journal_name_full 'Organic & Biomolecular Chemistry' _journal_paper_doi 10.1039/C7OB02729J _journal_year 2017 _chemical_formula_moiety 'C20 H15 N3 O' _chemical_formula_sum 'C20 H15 N3 O' _chemical_formula_weight 313.35 _chemical_name_systematic 3,8-Dimethyl-1-phenyl-1H-benzofuro[3,2-b]pyrazolo[4,3-e]pyridine _space_group_crystal_system monoclinic _space_group_IT_number 15 _space_group_name_Hall '-C 2yc' _space_group_name_H-M_alt 'C 1 2/c 1' _symmetry_space_group_name_Hall '-C 2yc' _symmetry_space_group_name_H-M 'C 1 2/c 1' _atom_sites_solution_hydrogens geom _audit_creation_method SHELXL-2013 _audit_update_record ; 2017-06-02 deposited with the CCDC. 2017-12-22 downloaded from the CCDC. ; _cell_angle_alpha 90 _cell_angle_beta 119.984(4) _cell_angle_gamma 90 _cell_formula_units_Z 8 _cell_length_a 32.653(2) _cell_length_b 4.8634(4) _cell_length_c 21.7870(16) _cell_measurement_reflns_used 2642 _cell_measurement_temperature 173(2) _cell_measurement_theta_max 28.49 _cell_measurement_theta_min 2.60 _cell_volume 2996.8(4) _computing_cell_refinement 'Bruker Apex V7.51A' _computing_data_collection 'Bruker Apex V7.51A' _computing_data_reduction 'Bruker SAINT' _computing_molecular_graphics 'ORTEP-3v2.01 (Farrugia, 1997)' _computing_publication_material SHELXL-2013 _computing_structure_refinement 'SHELXL-2013 (Sheldrick, 2013)' _computing_structure_solution 'SHELXS-2013 (Sheldrick, 2013)' _diffrn_ambient_temperature 173(2) _diffrn_measured_fraction_theta_full 0.999 _diffrn_measured_fraction_theta_max 0.999 _diffrn_measurement_device_type 'Bruker-Nonius Apex X8-CCD-diffractometer' _diffrn_measurement_method 'phi and omega scans' _diffrn_radiation_monochromator graphite _diffrn_radiation_source 'sealed tube' _diffrn_radiation_type MoK\a _diffrn_radiation_wavelength 0.71073 _diffrn_reflns_av_R_equivalents 0.0559 _diffrn_reflns_av_unetI/netI 0.0446 _diffrn_reflns_Laue_measured_fraction_full 0.999 _diffrn_reflns_Laue_measured_fraction_max 0.999 _diffrn_reflns_limit_h_max 44 _diffrn_reflns_limit_h_min -44 _diffrn_reflns_limit_k_max 6 _diffrn_reflns_limit_k_min -4 _diffrn_reflns_limit_l_max 29 _diffrn_reflns_limit_l_min -29 _diffrn_reflns_number 20234 _diffrn_reflns_point_group_measured_fraction_full 0.999 _diffrn_reflns_point_group_measured_fraction_max 0.999 _diffrn_reflns_theta_full 25.242 _diffrn_reflns_theta_max 28.998 _diffrn_reflns_theta_min 2.597 _exptl_absorpt_coefficient_mu 0.088 _exptl_absorpt_correction_T_max 0.7462 _exptl_absorpt_correction_T_min 0.6353 _exptl_absorpt_correction_type multi-scan _exptl_absorpt_process_details '(SADABS; Sheldrick, 2004)' _exptl_crystal_colour colourless _exptl_crystal_density_diffrn 1.389 _exptl_crystal_description needle _exptl_crystal_F_000 1312 _exptl_crystal_size_max 0.890 _exptl_crystal_size_mid 0.070 _exptl_crystal_size_min 0.040 _refine_diff_density_max 0.229 _refine_diff_density_min -0.233 _refine_diff_density_rms 0.046 _refine_ls_extinction_method none _refine_ls_goodness_of_fit_ref 1.019 _refine_ls_hydrogen_treatment constr _refine_ls_matrix_type full _refine_ls_number_parameters 219 _refine_ls_number_reflns 3999 _refine_ls_number_restraints 0 _refine_ls_restrained_S_all 1.019 _refine_ls_R_factor_all 0.0757 _refine_ls_R_factor_gt 0.0462 _refine_ls_shift/su_max 0.000 _refine_ls_shift/su_mean 0.000 _refine_ls_structure_factor_coef Fsqd _refine_ls_weighting_details 'w=1/[\s^2^(Fo^2^)+(0.0526P)^2^+1.5421P] where P=(Fo^2^+2Fc^2^)/3' _refine_ls_weighting_scheme calc _refine_ls_wR_factor_gt 0.1076 _refine_ls_wR_factor_ref 0.1274 _reflns_Friedel_coverage 0.000 _reflns_number_gt 2728 _reflns_number_total 3999 _reflns_threshold_expression 'I > 2\s(I)' _cod_data_source_file c7ob02729j2.cif _cod_data_source_block ah_mm378 _cod_database_code 7156038 _shelx_space_group_comment ; The symmetry employed for this shelxl refinement is uniquely defined by the following loop, which should always be used as a source of symmetry information in preference to the above space-group names. They are only intended as comments. ; _shelx_estimated_absorpt_t_min 0.926 _shelx_estimated_absorpt_t_max 0.996 _shelxl_version_number 2013-4 _shelx_res_file ; TITL a1 in C2/c CELL 0.71073 32.6530 4.8634 21.7870 90.000 119.984 90.000 ZERR 8.00 0.0024 0.0004 0.0016 0.000 0.004 0.000 LATT 7 SYMM -X, Y, 0.5-Z SFAC C H N O UNIT 160 120 24 8 LIST 4 TEMP -99.960 SIZE 0.04 0.07 0.89 OMIT -3 58 OMIT 2 0 0 OMIT 0 0 2 OMIT -2 0 2 L.S. 8 ACTA CONF BOND $H FMAP 2 PLAN 20 WGHT 0.052600 1.542100 FVAR 0.07015 O1 4 0.071253 0.900704 0.597276 11.00000 0.03363 0.03163 = 0.03003 0.00096 0.01543 0.00496 N1 3 0.043084 0.190025 0.362192 11.00000 0.02725 0.03350 = 0.02417 0.00258 0.00736 -0.00278 N2 3 0.083886 0.149864 0.426405 11.00000 0.02578 0.02776 = 0.02207 0.00070 0.00798 -0.00086 N3 3 0.119900 0.349013 0.544277 11.00000 0.02685 0.02719 = 0.02415 0.00234 0.01108 -0.00003 C1 1 0.070245 0.715821 0.548246 11.00000 0.03037 0.02675 = 0.02972 0.00205 0.01683 0.00071 C2 1 0.035044 0.691869 0.479177 11.00000 0.02505 0.03137 = 0.03159 0.00696 0.01356 0.00294 AFIX 43 H2 2 0.007442 0.803180 0.458531 11.00000 -1.20000 AFIX 0 C3 1 0.043669 0.487714 0.441999 11.00000 0.02459 0.02949 = 0.02682 0.00577 0.01167 -0.00095 C4 1 0.019349 0.390301 0.371113 11.00000 0.02622 0.03311 = 0.02753 0.00400 0.01021 -0.00335 C5 1 0.085436 0.328682 0.476514 11.00000 0.02602 0.02298 = 0.02637 0.00201 0.01220 -0.00254 C6 1 0.111016 0.547825 0.578513 11.00000 0.02809 0.02551 = 0.02766 0.00245 0.01432 -0.00073 C7 1 0.139157 0.638352 0.651117 11.00000 0.03074 0.02671 = 0.02743 0.00088 0.01618 -0.00200 C8 1 0.182277 0.559248 0.708900 11.00000 0.02948 0.03208 = 0.02809 0.00129 0.01380 0.00017 AFIX 43 H8 2 0.200258 0.416057 0.704071 11.00000 -1.20000 AFIX 0 C9 1 0.198708 0.690785 0.773353 11.00000 0.03225 0.03297 = 0.02840 0.00148 0.01531 -0.00405 C10 1 0.171575 0.902283 0.778897 11.00000 0.04136 0.03229 = 0.02985 -0.00354 0.01818 -0.00604 AFIX 43 H10 2 0.183048 0.991814 0.823268 11.00000 -1.20000 AFIX 0 C11 1 0.128850 0.985928 0.722526 11.00000 0.04330 0.02942 = 0.03551 -0.00074 0.02239 0.00200 AFIX 43 H11 2 0.110908 1.129897 0.727142 11.00000 -1.20000 AFIX 0 C12 1 0.113582 0.850176 0.659331 11.00000 0.03083 0.02872 = 0.02820 0.00350 0.01503 0.00094 C13 1 -0.025939 0.493957 0.311049 11.00000 0.02897 0.04716 = 0.03089 0.00451 0.00787 0.00115 AFIX 137 H13A 2 -0.021872 0.684910 0.300736 11.00000 -1.50000 H13B 2 -0.050725 0.484969 0.323851 11.00000 -1.50000 H13C 2 -0.035011 0.380181 0.269046 11.00000 -1.50000 AFIX 0 C14 1 0.116532 -0.050718 0.430330 11.00000 0.03046 0.02374 = 0.02874 0.00087 0.01572 -0.00321 C15 1 0.105324 -0.207406 0.370587 11.00000 0.03490 0.03282 = 0.02793 -0.00128 0.01444 -0.00304 AFIX 43 H15 2 0.076434 -0.177088 0.327760 11.00000 -1.20000 AFIX 0 C16 1 0.136443 -0.407829 0.373761 11.00000 0.04639 0.03407 = 0.03636 -0.00516 0.02465 -0.00349 AFIX 43 H16 2 0.128660 -0.515393 0.332964 11.00000 -1.20000 AFIX 0 C17 1 0.178640 -0.453073 0.435532 11.00000 0.04047 0.03047 = 0.04472 -0.00041 0.02691 0.00032 AFIX 43 H17 2 0.199809 -0.591358 0.437487 11.00000 -1.20000 AFIX 0 C18 1 0.189702 -0.295097 0.494386 11.00000 0.03335 0.03593 = 0.03678 0.00061 0.01408 0.00316 AFIX 43 H18 2 0.218844 -0.324503 0.536879 11.00000 -1.20000 AFIX 0 C19 1 0.158970 -0.093830 0.492583 11.00000 0.03250 0.03032 = 0.03097 -0.00256 0.01227 0.00018 AFIX 43 H19 2 0.166908 0.013197 0.533520 11.00000 -1.20000 AFIX 0 C20 1 0.244105 0.600120 0.837392 11.00000 0.03623 0.05047 = 0.02918 -0.00006 0.01365 -0.00203 AFIX 137 H20A 2 0.263869 0.504616 0.822020 11.00000 -1.50000 H20B 2 0.236917 0.475434 0.866090 11.00000 -1.50000 H20C 2 0.261049 0.761351 0.865708 11.00000 -1.50000 AFIX 0 HKLF 4 REM a1 in C2/c REM R1 = 0.0462 for 2728 Fo > 4sig(Fo) and 0.0757 for all 3999 data REM 219 parameters refined using 0 restraints END WGHT 0.0526 1.5422 REM Highest difference peak 0.229, deepest hole -0.233, 1-sigma level 0.046 Q1 1 0.1346 0.7990 0.6508 11.00000 0.05 0.23 Q2 1 0.0891 1.1630 0.7149 11.00000 0.05 0.22 Q3 1 0.0600 0.4010 0.4615 11.00000 0.05 0.19 Q4 1 0.1962 0.8794 0.7729 11.00000 0.05 0.19 Q5 1 0.0951 0.6809 0.5604 11.00000 0.05 0.18 Q6 1 0.0371 0.4804 0.4015 11.00000 0.05 0.18 Q7 1 -0.0476 0.3023 0.2822 11.00000 0.05 0.17 Q8 1 0.0106 0.1771 0.3725 11.00000 0.05 0.16 Q9 1 0.1630 -0.2542 0.4924 11.00000 0.05 0.16 Q10 1 0.0449 0.6637 0.5198 11.00000 0.05 0.16 Q11 1 0.2691 -0.6038 0.4806 11.00000 0.05 0.16 Q12 1 0.1902 -0.3320 0.4594 11.00000 0.05 0.15 Q13 1 0.1278 -0.2405 0.3682 11.00000 0.05 0.15 Q14 1 0.0367 1.0370 0.5770 11.00000 0.05 0.15 Q15 1 0.2192 0.6139 0.8068 11.00000 0.05 0.14 Q16 1 0.1044 -0.1709 0.4149 11.00000 0.05 0.14 Q17 1 0.2441 0.3968 0.8422 11.00000 0.05 0.14 Q18 1 0.0467 0.6155 0.4496 11.00000 0.05 0.14 Q19 1 0.1883 0.5641 0.7565 11.00000 0.05 0.14 Q20 1 0.1485 0.2099 0.5603 11.00000 0.05 0.14 ; _shelx_res_checksum 39285 loop_ _space_group_symop_operation_xyz 'x, y, z' '-x, y, -z+1/2' 'x+1/2, y+1/2, z' '-x+1/2, y+1/2, -z+1/2' '-x, -y, -z' 'x, -y, z-1/2' '-x+1/2, -y+1/2, -z' 'x+1/2, -y+1/2, z-1/2' loop_ _atom_site_label _atom_site_type_symbol _atom_site_fract_x _atom_site_fract_y _atom_site_fract_z _atom_site_U_iso_or_equiv _atom_site_adp_type _atom_site_occupancy _atom_site_site_symmetry_order _atom_site_calc_flag _atom_site_refinement_flags_posn _atom_site_refinement_flags_adp O1 O 0.07125(4) 0.9007(2) 0.59728(6) 0.0320(3) Uani 1 1 d . . N1 N 0.04308(4) 0.1900(3) 0.36219(7) 0.0307(3) Uani 1 1 d . . N2 N 0.08389(4) 0.1499(2) 0.42640(6) 0.0270(3) Uani 1 1 d . . N3 N 0.11990(4) 0.3490(2) 0.54428(6) 0.0268(3) Uani 1 1 d . . C1 C 0.07025(5) 0.7158(3) 0.54825(8) 0.0281(3) Uani 1 1 d . . C2 C 0.03504(5) 0.6919(3) 0.47918(8) 0.0296(3) Uani 1 1 d . . H2 H 0.0074 0.8032 0.4585 0.036 Uiso 1 1 calc R U C3 C 0.04367(5) 0.4877(3) 0.44200(8) 0.0275(3) Uani 1 1 d . . C4 C 0.01935(5) 0.3903(3) 0.37111(8) 0.0304(3) Uani 1 1 d . . C5 C 0.08544(5) 0.3287(3) 0.47651(8) 0.0255(3) Uani 1 1 d . . C6 C 0.11102(5) 0.5478(3) 0.57851(8) 0.0269(3) Uani 1 1 d . . C7 C 0.13916(5) 0.6384(3) 0.65112(8) 0.0276(3) Uani 1 1 d . . C8 C 0.18228(5) 0.5592(3) 0.70890(8) 0.0301(3) Uani 1 1 d . . H8 H 0.2003 0.4161 0.7041 0.036 Uiso 1 1 calc R U C9 C 0.19871(5) 0.6908(3) 0.77335(8) 0.0311(3) Uani 1 1 d . . C10 C 0.17158(6) 0.9023(3) 0.77890(9) 0.0343(4) Uani 1 1 d . . H10 H 0.1830 0.9918 0.8233 0.041 Uiso 1 1 calc R U C11 C 0.12885(6) 0.9859(3) 0.72253(9) 0.0349(4) Uani 1 1 d . . H11 H 0.1109 1.1299 0.7271 0.042 Uiso 1 1 calc R U C12 C 0.11358(5) 0.8502(3) 0.65933(8) 0.0291(3) Uani 1 1 d . . C13 C -0.02594(5) 0.4940(4) 0.31105(9) 0.0388(4) Uani 1 1 d . . H13A H -0.0219 0.6849 0.3007 0.058 Uiso 1 1 calc R U H13B H -0.0507 0.4850 0.3239 0.058 Uiso 1 1 calc R U H13C H -0.0350 0.3802 0.2690 0.058 Uiso 1 1 calc R U C14 C 0.11653(5) -0.0507(3) 0.43033(8) 0.0272(3) Uani 1 1 d . . C15 C 0.10532(5) -0.2074(3) 0.37059(8) 0.0324(3) Uani 1 1 d . . H15 H 0.0764 -0.1771 0.3278 0.039 Uiso 1 1 calc R U C16 C 0.13644(6) -0.4078(3) 0.37376(9) 0.0372(4) Uani 1 1 d . . H16 H 0.1287 -0.5154 0.3330 0.045 Uiso 1 1 calc R U C17 C 0.17864(6) -0.4531(3) 0.43553(9) 0.0361(4) Uani 1 1 d . . H17 H 0.1998 -0.5914 0.4375 0.043 Uiso 1 1 calc R U C18 C 0.18970(6) -0.2951(3) 0.49439(9) 0.0369(4) Uani 1 1 d . . H18 H 0.2188 -0.3245 0.5369 0.044 Uiso 1 1 calc R U C19 C 0.15897(5) -0.0938(3) 0.49258(8) 0.0329(3) Uani 1 1 d . . H19 H 0.1669 0.0132 0.5335 0.039 Uiso 1 1 calc R U C20 C 0.24410(6) 0.6001(4) 0.83739(9) 0.0398(4) Uani 1 1 d . . H20A H 0.2639 0.5046 0.8220 0.060 Uiso 1 1 calc R U H20B H 0.2369 0.4754 0.8661 0.060 Uiso 1 1 calc R U H20C H 0.2610 0.7614 0.8657 0.060 Uiso 1 1 calc R U loop_ _atom_site_aniso_label _atom_site_aniso_U_11 _atom_site_aniso_U_22 _atom_site_aniso_U_33 _atom_site_aniso_U_23 _atom_site_aniso_U_13 _atom_site_aniso_U_12 O1 0.0336(6) 0.0316(6) 0.0300(6) 0.0010(4) 0.0154(5) 0.0050(4) N1 0.0273(6) 0.0335(7) 0.0242(6) 0.0026(5) 0.0074(5) -0.0028(5) N2 0.0258(6) 0.0278(6) 0.0221(6) 0.0007(5) 0.0080(5) -0.0009(5) N3 0.0268(6) 0.0272(6) 0.0241(6) 0.0023(5) 0.0111(5) 0.0000(5) C1 0.0304(7) 0.0267(7) 0.0297(8) 0.0021(6) 0.0168(6) 0.0007(6) C2 0.0251(7) 0.0314(8) 0.0316(8) 0.0070(6) 0.0136(6) 0.0029(6) C3 0.0246(7) 0.0295(7) 0.0268(8) 0.0058(6) 0.0117(6) -0.0009(6) C4 0.0262(7) 0.0331(8) 0.0275(8) 0.0040(6) 0.0102(6) -0.0033(6) C5 0.0260(7) 0.0230(7) 0.0264(7) 0.0020(5) 0.0122(6) -0.0025(5) C6 0.0281(7) 0.0255(7) 0.0277(8) 0.0025(6) 0.0143(6) -0.0007(6) C7 0.0307(7) 0.0267(7) 0.0274(8) 0.0009(6) 0.0162(6) -0.0020(6) C8 0.0295(7) 0.0321(8) 0.0281(8) 0.0013(6) 0.0138(6) 0.0002(6) C9 0.0322(8) 0.0330(8) 0.0284(8) 0.0015(6) 0.0153(7) -0.0041(6) C10 0.0414(9) 0.0323(8) 0.0299(8) -0.0035(6) 0.0182(7) -0.0060(7) C11 0.0433(9) 0.0294(8) 0.0355(9) -0.0007(6) 0.0224(8) 0.0020(7) C12 0.0308(7) 0.0287(7) 0.0282(8) 0.0035(6) 0.0150(6) 0.0009(6) C13 0.0290(8) 0.0472(10) 0.0309(9) 0.0045(7) 0.0079(7) 0.0012(7) C14 0.0305(7) 0.0237(7) 0.0287(8) 0.0009(6) 0.0157(6) -0.0032(6) C15 0.0349(8) 0.0328(8) 0.0279(8) -0.0013(6) 0.0144(7) -0.0030(6) C16 0.0464(9) 0.0341(8) 0.0364(9) -0.0052(7) 0.0246(8) -0.0035(7) C17 0.0405(9) 0.0305(8) 0.0447(10) -0.0004(7) 0.0269(8) 0.0003(7) C18 0.0334(8) 0.0359(9) 0.0368(9) 0.0006(7) 0.0141(7) 0.0032(7) C19 0.0325(8) 0.0303(8) 0.0310(8) -0.0026(6) 0.0123(7) 0.0002(6) C20 0.0362(9) 0.0505(10) 0.0292(9) -0.0001(7) 0.0137(7) -0.0020(8) loop_ _atom_type_symbol _atom_type_description _atom_type_scat_dispersion_real _atom_type_scat_dispersion_imag _atom_type_scat_source C C 0.0033 0.0016 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' H H 0.0000 0.0000 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' N N 0.0061 0.0033 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' O O 0.0106 0.0060 'International Tables Vol C Tables 4.2.6.8 and 6.1.1.4' loop_ _geom_angle_atom_site_label_1 _geom_angle_atom_site_label_2 _geom_angle_atom_site_label_3 _geom_angle C1 O1 C12 105.34(11) C4 N1 N2 107.20(12) C5 N2 N1 110.39(11) C5 N2 C14 131.24(12) N1 N2 C14 118.34(12) C6 N3 C5 111.76(12) C2 C1 O1 125.97(13) C2 C1 C6 122.81(14) O1 C1 C6 111.22(13) C1 C2 C3 113.37(13) C1 C2 H2 123.3 C3 C2 H2 123.3 C2 C3 C5 120.08(14) C2 C3 C4 134.69(14) C5 C3 C4 105.22(13) N1 C4 C3 110.89(13) N1 C4 C13 121.28(14) C3 C4 C13 127.80(15) N3 C5 N2 126.74(13) N3 C5 C3 126.98(14) N2 C5 C3 106.28(12) N3 C6 C1 125.00(14) N3 C6 C7 129.33(13) C1 C6 C7 105.67(13) C12 C7 C8 119.20(14) C12 C7 C6 105.78(13) C8 C7 C6 135.01(14) C9 C8 C7 119.54(14) C9 C8 H8 120.2 C7 C8 H8 120.2 C8 C9 C10 119.04(14) C8 C9 C20 120.48(14) C10 C9 C20 120.44(14) C11 C10 C9 122.73(15) C11 C10 H10 118.6 C9 C10 H10 118.6 C12 C11 C10 116.63(15) C12 C11 H11 121.7 C10 C11 H11 121.7 C11 C12 O1 125.13(14) C11 C12 C7 122.86(14) O1 C12 C7 111.99(13) C4 C13 H13A 109.5 C4 C13 H13B 109.5 H13A C13 H13B 109.5 C4 C13 H13C 109.5 H13A C13 H13C 109.5 H13B C13 H13C 109.5 C19 C14 C15 119.96(14) C19 C14 N2 121.15(13) C15 C14 N2 118.90(13) C16 C15 C14 119.73(15) C16 C15 H15 120.1 C14 C15 H15 120.1 C17 C16 C15 120.73(15) C17 C16 H16 119.6 C15 C16 H16 119.6 C18 C17 C16 119.19(15) C18 C17 H17 120.4 C16 C17 H17 120.4 C17 C18 C19 121.11(15) C17 C18 H18 119.4 C19 C18 H18 119.4 C14 C19 C18 119.27(15) C14 C19 H19 120.4 C18 C19 H19 120.4 C9 C20 H20A 109.5 C9 C20 H20B 109.5 H20A C20 H20B 109.5 C9 C20 H20C 109.5 H20A C20 H20C 109.5 H20B C20 H20C 109.5 loop_ _geom_bond_atom_site_label_1 _geom_bond_atom_site_label_2 _geom_bond_distance O1 C1 1.3840(18) O1 C12 1.3896(17) N1 C4 1.318(2) N1 N2 1.3811(16) N2 C5 1.3768(19) N2 C14 1.4157(18) N3 C6 1.3385(19) N3 C5 1.3399(18) C1 C2 1.368(2) C1 C6 1.413(2) C2 C3 1.396(2) C2 H2 0.9500 C3 C5 1.414(2) C3 C4 1.419(2) C4 C13 1.490(2) C6 C7 1.445(2) C7 C12 1.393(2) C7 C8 1.394(2) C8 C9 1.384(2) C8 H8 0.9500 C9 C10 1.402(2) C9 C20 1.507(2) C10 C11 1.381(2) C10 H10 0.9500 C11 C12 1.376(2) C11 H11 0.9500 C13 H13A 0.9800 C13 H13B 0.9800 C13 H13C 0.9800 C14 C19 1.388(2) C14 C15 1.390(2) C15 C16 1.385(2) C15 H15 0.9500 C16 C17 1.380(2) C16 H16 0.9500 C17 C18 1.379(2) C17 H17 0.9500 C18 C19 1.388(2) C18 H18 0.9500 C19 H19 0.9500 C20 H20A 0.9800 C20 H20B 0.9800 C20 H20C 0.9800 loop_ _geom_torsion_atom_site_label_1 _geom_torsion_atom_site_label_2 _geom_torsion_atom_site_label_3 _geom_torsion_atom_site_label_4 _geom_torsion C4 N1 N2 C5 0.28(16) C4 N1 N2 C14 -178.06(12) C12 O1 C1 C2 -179.60(14) C12 O1 C1 C6 0.55(15) O1 C1 C2 C3 179.74(13) C6 C1 C2 C3 -0.4(2) C1 C2 C3 C5 0.5(2) C1 C2 C3 C4 -178.32(15) N2 N1 C4 C3 -0.47(16) N2 N1 C4 C13 177.62(13) C2 C3 C4 N1 179.43(16) C5 C3 C4 N1 0.48(16) C2 C3 C4 C13 1.5(3) C5 C3 C4 C13 -177.45(15) C6 N3 C5 N2 178.70(13) C6 N3 C5 C3 -0.7(2) N1 N2 C5 N3 -179.46(13) C14 N2 C5 N3 -1.4(2) N1 N2 C5 C3 0.02(15) C14 N2 C5 C3 178.08(13) C2 C3 C5 N3 0.1(2) C4 C3 C5 N3 179.19(14) C2 C3 C5 N2 -179.43(12) C4 C3 C5 N2 -0.29(15) C5 N3 C6 C1 0.8(2) C5 N3 C6 C7 -179.05(14) C2 C1 C6 N3 -0.3(2) O1 C1 C6 N3 179.60(13) C2 C1 C6 C7 179.61(14) O1 C1 C6 C7 -0.53(16) N3 C6 C7 C12 -179.85(14) C1 C6 C7 C12 0.30(15) N3 C6 C7 C8 -1.0(3) C1 C6 C7 C8 179.19(16) C12 C7 C8 C9 0.5(2) C6 C7 C8 C9 -178.31(15) C7 C8 C9 C10 -0.3(2) C7 C8 C9 C20 177.18(14) C8 C9 C10 C11 0.0(2) C20 C9 C10 C11 -177.47(15) C9 C10 C11 C12 0.1(2) C10 C11 C12 O1 178.62(14) C10 C11 C12 C7 0.1(2) C1 O1 C12 C11 -179.05(14) C1 O1 C12 C7 -0.35(16) C8 C7 C12 C11 -0.3(2) C6 C7 C12 C11 178.77(14) C8 C7 C12 O1 -179.07(12) C6 C7 C12 O1 0.03(16) C5 N2 C14 C19 -0.3(2) N1 N2 C14 C19 177.60(13) C5 N2 C14 C15 179.18(14) N1 N2 C14 C15 -2.90(19) C19 C14 C15 C16 0.6(2) N2 C14 C15 C16 -178.89(13) C14 C15 C16 C17 -0.3(2) C15 C16 C17 C18 -0.3(2) C16 C17 C18 C19 0.6(2) C15 C14 C19 C18 -0.3(2) N2 C14 C19 C18 179.18(14) C17 C18 C19 C14 -0.3(2)